Histone Acetylation Retards the Adipogenic Differentiation of Human Umbilical Cord - Mesenchymal Stem Cells: A Clue for Anti-obesity Approach?
Key Points
This research investigates how histone acetylation affects the adipogenic differentiation of human umbilical cord mesenchymal stem cells.
Assessment of histone acetylation levels in MSCs
Application of histone deacetylation inhibitors
Evaluation of adipogenic differentiation markers
Histone deacetylation inhibitors significantly reduce adipogenic differentiation in MSCs
Increased acetylation correlates with a decrease in fat cell development
Abstract
Taken together, the results show a possible anti-obesity effect of histone deacetylation inhibitors (HDCAs) in MSCs, resulting in depletion and restriction of their adipogenic differentiation.
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Histone Acetylation Retards the Adipogenic Differentiation of Human Umbilical Cord - Mesenchymal Stem Cells: A Clue for Anti-obesity Approach? | Synapse
Cite This Study
Chandramoorthy et al. (Wed,) studied this question.