What question did this study set out to answer?

This research aims to evaluate the effects of polyphenols on TMAO levels in postmenopausal women, focusing on specific metabotypes.

February 5, 2026

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Precision health targeting TMAO in postmenopausal women: Polyphenol effects modulated by urolithin A and equol metabotypes in a randomised, placebo-controlled crossover trial

MJMaría Paula Jarrín-OrozcoCentro de Edafología y Biología Aplicada del Segura MGMaría García-NicolásCentro de Edafología y Biología Aplicada del Segura MRMaria Romo-Vaquero Romo-VaqueroCentro de Edafología y Biología Aplicada del Segura

Key Points

This research aims to evaluate the effects of polyphenols on TMAO levels in postmenopausal women, focusing on specific metabotypes.
Randomised, placebo-controlled crossover trial design
Assessment of polyphenol effects on TMAO production
Evaluation of gut microbiota composition
Analysis of metabolite responses based on urolithin A and equol metabotypes
Polyphenol intake was associated with reduced TMAO levels
Effects varied according to individual metabotypes (urolithin A and equol)
Improvement in cardiometabolic markers was observed in participants consuming polyphenols

Abstract

Menopause increases cardiometabolic risk, partly by reducing the protective effects of estrogens and inducing gut microbiota dysbiosis, which can promote the production of atherogenic metabolites such as trimethylamine N-oxide (TMAO)....

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Cite This Study

Jarrín-Orozco et al. (Thu,) studied this question.

synapsesocial.com/papers/6984348bf1d9ada3c1fb2caf https://doi.org/https://doi.org/10.1039/d5fo05461c

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