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February 5, 2026Food & Function4 citations

Precision health targeting TMAO in postmenopausal women: Polyphenol effects modulated by urolithin A and equol metabotypes in a randomised, placebo-controlled crossover trial

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MJMaría Paula Jarrín-OrozcoMGMaría García-NicolásMRMaria Romo-Vaquero Romo-Vaquero

Key Points

  • This research aims to evaluate the effects of polyphenols on TMAO levels in postmenopausal women, focusing on specific metabotypes.
  • Randomised, placebo-controlled crossover trial design
  • Assessment of polyphenol effects on TMAO production
  • Evaluation of gut microbiota composition
  • Analysis of metabolite responses based on urolithin A and equol metabotypes
  • Polyphenol intake was associated with reduced TMAO levels
  • Effects varied according to individual metabotypes (urolithin A and equol)
  • Improvement in cardiometabolic markers was observed in participants consuming polyphenols

Abstract

Menopause increases cardiometabolic risk, partly by reducing the protective effects of estrogens and inducing gut microbiota dysbiosis, which can promote the production of atherogenic metabolites such as trimethylamine N-oxide (TMAO)....

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Cite This Study

Jarrín-Orozco et al. (2026) studied this question.

synapsesocial.com/papers/6984348bf1d9ada3c1fb2cafhttps://doi.org/10.1039/d5fo05461c
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