What question did this study set out to answer?

The research aims to explore the relationship between FUS and TDP-43 aggregation and toxicity in aging yeast models.

February 8, 2026BMC Biology0 citationsOpen Access

FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

DMD. G. McDonaldMedical University of South Carolina NCNikita ChughWestern University RSRares SavaWestern University

Key Points

The research aims to explore the relationship between FUS and TDP-43 aggregation and toxicity in aging yeast models.
Utilized yeast models to investigate FUS and TDP-43 behavior.
Analyzed the effects of aggregation on cell toxicity and longevity.
Compared outcomes with different concentrations and conditions.
FUS and TDP-43 aggregation did not correlate with increased toxicity.
Aggregates were associated with enhanced longevity in yeast.
The findings suggest protective roles of these aggregates against cellular damage.

Abstract

Our work provides new insights into factors that uncouple FUS and TDP-43 aggregation from toxicity and support a rather protective role for FUS and TDP-43 aggregates in promoting longevity.

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Cite This Study

McDonald et al. (Fri,) studied this question.

synapsesocial.com/papers/698827b40fc35cd7a8846a0c https://doi.org/https://doi.org/10.1186/s12915-026-02537-3

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