FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

D. G. McDonald; Nikita Chugh; Rares Sava; Martin L. Duennwald

doi:10.1186/s12915-026-02537-3

February 6, 2026BMC BiologyOpen Access

FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

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Key Points

The research aims to explore the relationship between FUS and TDP-43 aggregation and toxicity in aging yeast models.
Utilized yeast models to investigate FUS and TDP-43 behavior.
Analyzed the effects of aggregation on cell toxicity and longevity.
Compared outcomes with different concentrations and conditions.
FUS and TDP-43 aggregation did not correlate with increased toxicity.
Aggregates were associated with enhanced longevity in yeast.
The findings suggest protective roles of these aggregates against cellular damage.

Implication

This research uncovers non-toxic roles of FUS and TDP-43 aggregates in aging yeast, suggesting protective mechanisms.

Abstract

Our work provides new insights into factors that uncouple FUS and TDP-43 aggregation from toxicity and support a rather protective role for FUS and TDP-43 aggregates in promoting longevity.

Discussion

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Cite This Study

McDonald et al. (2026) studied this question.

synapsesocial.com/papers/698827b40fc35cd7a8846a0c https://doi.org/10.1186/s12915-026-02537-3

View Full Paper

Ask AI

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FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

Key Points

Implication

Abstract

Discussion

Cite This Study

FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models

Key Points

Implication

Abstract

Discussion

Cite This Study

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