Pulmonary embolism mortality with comorbid atrial fibrillation increased from AAMR 0.4 in 1999 to 1.1 in 2020, with a sharper rise post-2018 (APC 11.97%).
Mortality related to pulmonary embolism with comorbid atrial fibrillation in the US has steadily increased from 1999 to 2020, particularly among men, non-Hispanic White adults, and those in metropolitan areas.
Absolute Event Rate: 0% vs 0%
Abstract Background Pulmonary embolism (PE) continues to be a major contributor to mortality in the United States. Among the various risk factors associated with this life-threatening condition, atrial fibrillation (AF) stands as a significant contributor, further complicating the health challenges faced by patients. Purpose This study aims to uncover critical trends and regional disparities in mortality related to PE with concomitant AF across the United States from 1999 to 2020. Methods Death certificate data from the Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research (CDC WONDER) database was to evaluate mortality associated with pulmonary embolism (PE) and atrial fibrillation/flutter (AF) from 1999 to 2020 for adults 15 years. Age-adjusted mortality rates (AAMRs) per 100,000 individuals, and Annual Percent Change (APCs) along with their 95% confidence intervals (CIs) were also calculated. Data were stratified by year, sex, race, and census region. Results PE with comorbid AF in adults aged ≥ 15 years resulted in 38,848 deaths, with an overall AAMR 0.70 (APC - 4.45; 95% CI: 3.94 – 4.96). The AAMR increased from 0.4 in 1999 to 0.8 in 2018 (APC: 4.2; 95% CI: 3.6 to 4.8), and further increased to 1.1 in 2020 (APC: 11.97; 95% CI: -7.3 – 35.2). Similar AAMR values were reported in both male and female in 1999 (AAMR: 0.4), however, men showed a slightly higher increase by 2020 (AAMR men: 1.4 vs women: 1.0). Non-Hispanic (NH) White adults had the highest overall AAMR (0.7), followed by NH Black (0.6), NH American Indian/Alaska Native (0.4), Hispanic or Latino (0.3), and NH Asian or Pacific Islander adults (0.2). AAMR did not vary substantially by region (overall AAMR: Midwest 0.7; South: 0.7; West: 0.7; Northeast: 0.6), and metropolitan areas had higher PE with comorbid AF-related AAMR (1.0) than nonmetropolitan areas (0.8). Wyoming, Colorado, and Vermont ranked in the top 90th percentile for PE with comorbid AF-related AAMR, with rates nearly four times higher than states in the lowest 10th percentile. Conclusion There’s been a steady increase in PE mortality with comorbid AF over the last 20 years. AAMR values were greater among non-Hispanic Adults, and those residing in metropolitan areas of the US. Notably, a sharper rise in AAMR post-2018 has been reported in both males and females. These findings highlight the importance of addressing and developing targeted interventions to curb the increased PE with comorbid AF mortality rates in the vulnerable population.
Siraj et al. (Sat,) reported a other. Pulmonary embolism mortality with comorbid atrial fibrillation increased from AAMR 0.4 in 1999 to 1.1 in 2020, with a sharper rise post-2018 (APC 11.97%).