Key result
PE mortality with comorbid AFib climbs ~175% from 1999 to 2020.
Why the study?
Pulmonary embolism contributes significantly to US mortality and concomitant atrial fibrillation further complicates outcomes, but nationwide trends and regional disparities in combined mortality remain to be characterized.
Population
38,848 deaths from PE with comorbid AF in US adults aged ≥ 15 years
Design
CDC WONDER database mortality analysis
Authors
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Rising PE-AF mortality trends warrant clinical awareness; leaves open whether targeted interventions alter outcomes in this population.
Mortality related to pulmonary embolism with comorbid atrial fibrillation in the US has steadily increased from 1999 to 2020, particularly among men, non-Hispanic White adults, and those in metropolitan areas.
Siraj et al. (2025) studied this question. Pulmonary embolism mortality with comorbid atrial fibrillation increased from AAMR 0.4 in 1999 to 1.1 in 2020, with a sharper rise post-2018 (APC 11.97%).
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