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December 8, 2025BloodOpen Access

Retrospective analysis in mortality from phlebitis/thrombophlebitis and atrial fibrillation/flutter in u.S. adults aged ≥45 years from 1999–2023: A CDC wonder study

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Authors

NTNayanika TummalaRJRumman JavedAMAbdul Majid

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Overview

Retrospective analysis reveals increased mortality from atrial fibrillation, thromboembolic events, and phlebitis in U.S. adults aged 45+, indicating significant disparities among demographics.

Key Points

  • This research aims to analyze mortality trends from phlebitis/thrombophlebitis and atrial fibrillation in U.S. adults aged 45 and older.
  • Retrospective analysis of death certificates from CDC's database from 1999 to 2023
  • Utilized ICD-10 codes to examine causes of death
  • Calculated Annual Percent Change and Average Annual Percent Change for trend identification
  • Employed Joinpoint regression analysis to detect significant changes in mortality trends
  • Stratified data by gender, race, urbanization, and regions for detailed insights.
  • 35,059 deaths recorded between 1999 and 2023
  • Overall AAPC was 5.15* with significant increases noted across demographics
  • Evident disparities in AAMR across genders and races, with Whites showing the highest rates
  • Metropolitan status influenced mortality trends significantly, with Micropolitan areas having the highest AAMR.

Cite This Study

Tummala et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc25https://doi.org/10.1182/blood-2025-8007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Fri091: Unraveling the Rising Tide: Trends and Disparities in Atrial Fibrillation Mortality in the United States, 1968–20232025
  2. 2A66-03 Nationwide Trends and Disparities of Pulmonary Artery Hypertension and Atrial Fibrillation Mortality: A Retrospective Study2026
  3. 3Trends in United States mortality among patients with atrial fibrillation/flutter related heart failure (1999–2024): disparities by gender, race/ethnicity and region2025 · 22 citations
  4. 4Atrial fibrillation/atrial flutter related mortality trends in the US population 2010–2020: Regional, racial, sex variations2022 · 16 citations
  5. 5Trends and disparities in lung cancer and atrial fibrillation/flutter–related mortality in the United States, 2000–2023.2026