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December 17, 2022Pacing and Clinical Electrophysiology

Atrial fibrillation/atrial flutter related mortality trends in the US population 2010–2020: Regional, racial, sex variations

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Key result

Underlying AF/AFL mortality plateaus after 2016 while contributing deaths rise ~3% annually.

Why the study?

Evaluating AF/AFL mortality trends across races, sexes, geographic regions, and urbanization statuses was needed to better understand management inequalities.

Population

US population with AF/AFL-related mortality in the CDC WONDER database between 2010 and 2020

Comparison

Mortality trends compared across different races, sexes, census regions, and urbanization statuses

Design

Observational database study

Authors

Alireza GhajarAlireza GhajarElectrophysiologyMEMohammed EssaBeth Israel Deaconess Medical CenterADAugustin DeLagoInterventional Cardiology

Discussion

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Implication

Rising AF/AFL contribution to US mortality with disparities warrants targeted surveillance; leaves open drivers and interventions for prospective study.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

P
Population
US population with mortality due to atrial fibrillation/atrial flutter (AF/AFL) as underlying or contributing causes of death between 2010 and 2020
O
Outcome
Mortality rates due to AF/AFL as underlying and contributing causes of deathhard clinical

While AF/AFL as an underlying cause of death has plateaued since 2016 in the US, its role as a contributing cause of death continues to rise, with significant regional and racial disparities.

Cite This Study

Ghajar et al. (2022) conducted an observational in Atrial fibrillation/atrial flutter (AF/AFL). AF/AFL as the underlying cause of death increased across the US until 2016 (APC 4.8%) and then plateaued, while AF/AFL as a contributing cause of death increased from 2010 to 2020 (APC 3.3%).

synapsesocial.com/papers/6a11c9628b61bd91eb562e2ehttps://doi.org/10.1111/pace.14643

Topics

Atrial fibrillationPersistent AF managementAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial Fibrillation and Ethnicity: The Known, the Unknown and the Paradox2009 · 80 citations
  2. 2Racial Disparities in Awareness and Treatment of Atrial Fibrillation2010 · 157 citations
  3. 3Racial/Ethnic Differences in the Risk of Intracranial Hemorrhage Among Patients With Atrial Fibrillation2007 · 663 citations
  4. 4Genetic heterogeneity of atrial fibrillation susceptibility loci across racial or ethnic groups2017 · 16 citations
  5. 5Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality2003 · 1,988 citations