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May 6, 2026Circulation

Abstract WE474: Trends and Disparities in Heart Failure and Atrial Fibrillation-Related Mortality in the United States – A Nationwide Retrospective Analysis

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Key result

US concurrent HF and AF mortality rose ~4% annually from 1999 to 2023.

  • AAPC 4.2%
  • P<0.05
  • n=1,110,367

Population

Individuals aged 25 and older in the United States with concurrent heart failure and atrial…

Design

Cohort

Follow-up

1999-2023

Authors

AKAria KenarsaryUniversity of Wisconsin System

Discussion

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Implication

Mortality related to concurrent heart failure and atrial fibrillation has steadily increased in the US over the past two decades, highlighting persistent demographic and geographic disparities.

Key Points

  • To evaluate trends in mortality related to heart failure and atrial fibrillation across different demographics in the US.
  • Nationwide retrospective analysis using CDC WONDER database
  • Ages 25 and older, from 1999 to 2023
  • Calculated age-adjusted mortality rates by year, race, gender, urbanization, and geographic region
  • Utilized Joinpoint regression software for trend assessment
  • 1,110,367 deaths related to concurrent heart failure and atrial fibrillation from 1999 to 2023
  • Overall AAMR increased at an average annual percentage change of 4.2%
  • Higher mortality rates observed in non-Hispanic White and non-Hispanic Black individuals
  • Most deaths occurred in inpatient medical facilities (30%) and nursing homes (26.52%)

Study Design

Type

Observational (n=1,110,367)

Multicenter

Yes

Structured PICO

P
Population
1,110,367 deaths related to concurrent heart failure and atrial fibrillation among individuals aged 25 and older in the United States from 1999 to 2023.
O
Outcome
Age-adjusted mortality rates (AAMR) per 100,000 individuals related to concurrent atrial fibrillation and heart failurehard clinical

Main Result

Effect estimate: AAPC 4.2%

p-value: p=<0.05

Mortality related to concurrent heart failure and atrial fibrillation has steadily increased in the US over the past two decades, highlighting persistent demographic and geographic disparities.

Cite This Study

Aria Kenarsary (2026) conducted an observational in Concurrent heart failure and atrial fibrillation (n=1,110,367). Time period (1999-2023) was evaluated on Age-adjusted mortality rates (AAMR) (AAPC 4.2%, p=<0.05). Age-adjusted mortality rates for concurrent heart failure and atrial fibrillation in the US steadily increased from 1999 to 2023 (AAPC 4.2%), with the highest rates in men and NH White individuals.

synapsesocial.com/papers/69faa30204f884e66b533892https://doi.org/10.1161/cir.153.suppl_1.we474
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in United States mortality among patients with atrial fibrillation/flutter related heart failure (1999–2024): disparities by gender, race/ethnicity and region2025 · 23 citations
  2. 2Atrial fibrillation mortality trends in individuals with heart failure2023 · 4 citations
  3. 3Abstract 4365855: Two-Decade Trends in Mortality Due to Atrial Fibrillation Among Older Adults With Heart Failure in the United States (1999–2023)2025 · 1 citations
  4. 4Abstract Fri091: Unraveling the Rising Tide: Trends and Disparities in Atrial Fibrillation Mortality in the United States, 1968–20232025
  5. 5Heart Failure–Related Death in Subjects With Atrial Fibrillation in the United States, 1999 to 20202024 · 22 citations