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December 6, 2024American Heart Journal Plus Cardiology Research and PracticeOpen Access

Trends in stroke-related mortality in atrial fibrillation patients in the United States: Insights from the CDC WONDER database

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Why the study?

Stroke associated with AF is a significant cause of mortality, prompting analysis of demographic trends and disparities in stroke-related mortality among patients aged >=25 years.

Population

331,106 deaths from AF-associated stroke among US adults aged >=25 years

Comparison

Mortality trends stratified by year, sex, race/ethnicity, and geographical regions

Design

Retrospective database analysis

Authors

MNMuhammad Abdullah NaveedSNSivaram NeppalaHCHimaja Dutt Chigurupati

Discussion

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Member takes

Overview

May flag high-risk groups for better AF anticoagulation access now; leaves open drivers of racial differences and the post-2018 mortality rebound.

Structured PICO

P
Population
331,106 adults aged ≥25 years in the United States who died from stroke (ischemic, hemorrhagic, or both) associated with atrial fibrillation between 1999 and 2020.
O
Outcome
Age-adjusted mortality rate (AAMR) per 100,000 persons for stroke-related deaths in atrial fibrillation patientshard clinical

Stroke-related mortality in atrial fibrillation patients decreased overall from 1999 to 2020, but showed a concerning increase from 2018 to 2020, with significant disparities by sex, race, and geography.

Limitations

  • Retrospective design
  • Reliance on death certificates introduces potential for inaccurate diagnosis and misclassification bias
  • Absence of laboratory values, medication lists, and clinical data about general health conditions, comorbidities, and treatment

Cite This Study

Naveed et al. (2024) studied this question.

synapsesocial.com/papers/6a7fe9b5ebb101a2a079a26fhttps://doi.org/10.1016/j.ahjo.2024.100491
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial and sex differences in optimizing anticoagulation therapy for patients with atrial fibrillation2022 · 3 citations
  2. 2Pathogenetic mechanism of stroke in non‐valvular atrial fibrillation: follow‐up of stroke patients with and without atrial fibrillation1991 · 35 citations
  3. 3Duration of atrial fibrillation and imminence of stroke: the Framingham study.1983 · 340 citations
  4. 4Atrial fibrillation and stroke: prevalence in different types of stroke and influence on early and long term prognosis (Oxfordshire community stroke project)1992 · 256 citations
  5. 5Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation2007 · 4,828 citations