November 27, 2024Pacing and Clinical ElectrophysiologyOpen Access

Trends and Disparities in Atrial Fibrillation and Stroke Related Mortality in the United States from 1999 to 2020

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Why the study?

Data regarding contemporary national mortality estimates related to stroke and AF were lacking, which are important for targeted health policy interventions.

Population

488,469 AF and stroke-related deaths in US adults ≥25 years old

Comparison

Temporal trends and demographic/geographical disparities from 1999 to 2020

Design

Retrospective database study using CDC WONDER

Authors

BRBirju RaoElectrophysiology EQEduardo QuinteroEmory University ASAnand ShahUniversity of Stuttgart

Discussion

Member takes

Implication

Rising AF-stroke mortality after 2008 signals incomplete prevention gains; leaves open drivers of the reversal and persistent disparities.

Structured PICO

Population

488,469 adults ≥25 years old in the United States who died between 1999 and 2020 with both atrial fibrillation/flutter and stroke (ischemic, hemorrhagic, or nonspecified) listed as an underlying or contributing cause of death.

Outcome

Age-adjusted mortality rates (AAMR) and annual percent change (APC) in atrial fibrillation and stroke-related deathshard clinical

After an initial decline, atrial fibrillation and stroke-related mortality in the US has increased since 2008, with significant demographic and geographic disparities highlighting the need for targeted prevention strategies.

Limitations

Use of ICD codes and reliance on death certificate data which may be sources of misclassification bias
Lack of information about ejection fraction, ICD use, medication use, and socioeconomic factors
Inability to capture non-fatal strokes that occurred over the same time period

Cite This Study

Rao et al. (2024) studied this question.

synapsesocial.com/papers/6a7fcc9cce7408e5451f7197 https://doi.org/10.1111/pace.15111

View Full Paper

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Implication

Rising AF-stroke mortality after 2008 signals incomplete prevention gains; leaves open drivers of the reversal and persistent disparities.

Trends and Disparities in Atrial Fibrillation and Stroke Related Mortality in the United States from 1999 to 2020

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Trends and Disparities in Atrial Fibrillation and Stroke Related Mortality in the United States from 1999 to 2020

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider