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April 28, 2025Journal of Stroke and Cerebrovascular DiseasesOpen Access

A silent surge: Increasing stroke deaths among older adults with atrial fibrillation in the United States (1999-2020)

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Why the study?

AF significantly increases stroke risk and mortality in older adults, but trends and disparities in AF-related stroke mortality required investigation.

Population

197,453 stroke deaths with contributing AF among U.S. adults aged 65 and older

Comparison

Mortality trends across sex, race, and geography from 1999 to 2020

Design

Retrospective database analysis using CDC WONDER

Authors

MSMuhammad Umer SohailConemaugh Health SystemZIZeina IbrahimDow University of Health SciencesSWSaad Ahmed WaqasSchool of the Art Institute of Chicago

Discussion

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Member takes

Overview

Should not yet change practice in older adults with AF; leaves open the drivers of observed mortality patterns and disparities.

Structured PICO

P
Population
U.S. adults aged 65 and older with stroke as the underlying cause of death and atrial fibrillation (AF) as a contributing cause (n=197,453 deaths)
O
Outcome
Age-adjusted mortality rates (AAMRs) per 100,000 persons for AF-related strokehard clinical

AF-related stroke mortality in older U.S. adults has steadily increased from 1999 to 2020, with notable disparities across gender, race, and geography.

Cite This Study

Sohail et al. (2025) studied this question.

synapsesocial.com/papers/6a7fe9b5ebb101a2a079a26ehttps://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108328
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1National Trends in Mortality Due to Ischemic Stroke Among Older Adults With Atrial Fibrillation in the USA, 1999–20202025 · 2 citations
  2. 2Trends in stroke-related mortality in atrial fibrillation patients in the United States: Insights from the CDC WONDER database2024 · 6 citations
  3. 3Abstract TP167: Trends and Disparities in Mortality from Atrial Fibrillation-Related Stroke in the United States from 1999 to 2023: Insights from the CDC WONDER Database2026
  4. 4Temporal Trends in Mortality Related to Stroke and Atrial Fibrillation in the United States: A 21‐Year Retrospective Analysis of CDC‐WONDER Database2024 · 18 citations
  5. 5Abstract Fri091: Unraveling the Rising Tide: Trends and Disparities in Atrial Fibrillation Mortality in the United States, 1968–20232025