What question did this study set out to answer?

To examine trends in mortality from atrial fibrillation-related strokes in U.S. adults aged 55 and older from 1999 to 2023, highlighting demographic differences.

February 2, 2026Stroke

Abstract TP167: Trends and Disparities in Mortality from Atrial Fibrillation-Related Stroke in the United States from 1999 to 2023: Insights from the CDC WONDER Database

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Key result

AF-related stroke mortality declines significantly from 2019 to 2023, but sex, race, and age disparities persist.

Why the study?

Combined mortality from AF-related stroke is high, making the understanding of mortality trends crucial for informing public health strategies.

Population

130,951 deaths from AF-related strokes in US adults age 55 years or older

Comparison

Stratified by age, sex, ethnicity, and geography

Design

Retrospective database analysis using CDC WONDER

Authors

SKSohail KumarJohn F. Kennedy Medical Center MAMaryam AsgharNishtar Medical College and Hospital HIHania ImtiazDow University of Health Sciences

Discussion

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Implication

Recent AF-stroke mortality declines merit ongoing demographic surveillance; leaves open drivers of trends and persistent disparities.

Key Points

To examine trends in mortality from atrial fibrillation-related strokes in U.S. adults aged 55 and older from 1999 to 2023, highlighting demographic differences.
Extracted mortality data from the CDC WONDER database.
Calculated crude mortality rates and age-adjusted mortality rates per 100,000 individuals.
Stratified data by age, sex, ethnicity, and geography.
Performed joinpoint regression to estimate annual percent change in mortality rates.
Recorded 130,951 deaths from AF-related strokes from 1999 to 2023.
Age-adjusted mortality rates rose from 1999-2019 and then declined until 2023.
Males experienced a lower mortality rate than females, but both showed trends of increase followed by decline.
Non-Hispanic Whites had the highest mortality rates, while Hispanics had the lowest; all groups showed significant mortality trends over time.

Structured PICO

Population

U.S. adults (age ≥55 years) with deaths from atrial fibrillation-related strokes from 1999 to 2023 (n=130,951 deaths)

Outcome

Combined mortality from atrial fibrillation and stroke (crude mortality rate and age-adjusted mortality rates per 100,000 individuals)hard clinical

Mortality from AF-related stroke in the US increased slightly from 1999 to 2019 but has declined since 2020, though significant disparities by sex, race, and geography persist.

Cite This Study

Kumar et al. (2026) studied this question. Atrial fibrillation-related stroke mortality slightly rose from 1999-2019 before declining significantly through 2023, with disparities by sex, race, and age persisting.

synapsesocial.com/papers/6980fbf6c1c9540dea80dcc2 https://doi.org/10.1161/str.57.suppl_1.tp167

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF

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Abstract TP167: Trends and Disparities in Mortality from Atrial Fibrillation-Related Stroke in the United States from 1999 to 2023: Insights from the CDC WONDER Database

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Abstract TP167: Trends and Disparities in Mortality from Atrial Fibrillation-Related Stroke in the United States from 1999 to 2023: Insights from the CDC WONDER Database

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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