What is the clinical evidence from this study?

Study design: Observational. Population: Heart failure and pulmonary embolism (n=38129). Intervention: Time period (2010-2020). Primary outcome: Age-adjusted mortality rates for pulmonary embolism-attributable mortality (Average annual percentage change +4.7%, 95% CI 3.3%-6.1%, p=<0.001).

What question did this study set out to answer?

The study evaluates trends in pulmonary embolism-attributable mortality among heart failure patients in the U.S. from 2010 to 2020.

June 19, 2026JACC AdvancesOpen Access

PE-attributable mortality in US HF patients rose ~5% annually between 2010 and 2020.

Q: What are the key findings of this study?

Between 2010 and 2020, age-adjusted pulmonary embolism-attributable mortality among U.S. patients with heart failure increased by an average of 4.7% annually (95% CI: 3.3%-6.1%; P<0.001).

Q: What does this research mean for the field?

Between 2010 and 2020, age-adjusted pulmonary embolism-attributable mortality among U.S. patients with heart failure increased by an average of 4.7% annually. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

The study evaluates trends in pulmonary embolism-attributable mortality among heart failure patients in the U.S. from 2010 to 2020.

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Why the study?

Contemporary trends in pulmonary embolism-attributable mortality among US patients with heart failure remain underexplored.

Population

38,129 US patients with HF aged ≥25 years who died from PE

Comparison

Mortality trends stratified by age, sex, race/ethnicity, urbanicity, and region

Design

Retrospective database analysis using CDC WONDER and NHANES

Key result

Between 2010 and 2020, age-adjusted pulmonary embolism-attributable mortality among U.S. patients with heart failure increased by an average of 4.7% annually (95% CI: 3.3%-6.1%; P<0.001).

Authors

MZMarco Zuin ANAnju Nohria SHStanislav Henkin

Discussion

Member takes

Overview

May warrant closer PE monitoring in HF; leaves open optimal prevention strategies.

Key Points

The study evaluates trends in pulmonary embolism-attributable mortality among heart failure patients in the U.S. from 2010 to 2020.
Analyzed data from the CDC database for patients with heart failure aged ≥25 years.
Used joinpoint regression to assess age-adjusted mortality rates and trends.
Examined concurrent trends in heart failure prevalence using National Health and Nutrition Examination Survey data.
38,129 heart failure patients died from pulmonary embolism, with a proportionate mortality of 9.8%.
Age-adjusted mortality rates increased by 4.7% annually, with significant rises for younger adults and certain racial groups.
Concomitant increases in risk factors such as obesity, smoking, and chronic kidney disease were noted.

Study Design

Type

Observational (n=38,129)

Multicenter

Yes

Structured PICO

Population

38,129 U.S. adults aged ≥25 years with heart failure who died from pulmonary embolism between 2010 and 2020.

Outcome

Trends in pulmonary embolism (PE)-attributable mortality (Age-adjusted mortality rates)hard clinical

Main Result

Effect estimate: Average annual percentage change +4.7% (95% CI 3.3%-6.1%)

p-value: p=<0.001

Pulmonary embolism-attributable mortality among U.S. patients with heart failure has risen significantly from 2010 to 2020, particularly among younger adults and certain ethnoracial groups.

Cite This Study

Zuin et al. (2026) conducted an observational in Heart failure and pulmonary embolism (n=38,129). Time period (2010-2020) was evaluated on Age-adjusted mortality rates for pulmonary embolism-attributable mortality (Average annual percentage change +4.7%, 95% CI 3.3%-6.1%, p=<0.001). Between 2010 and 2020, age-adjusted pulmonary embolism-attributable mortality among U.S. patients with heart failure increased by an average of 4.7% annually (95% CI: 3.3%-6.1%; P<0.001).

synapsesocial.com/papers/6a35982fdd3be7785e70ecc9 https://doi.org/10.1016/j.jacadv.2026.102841

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June 19, 2026JACC AdvancesOpen Access

PE-attributable mortality in US HF patients rose ~5% annually between 2010 and 2020.

View Full Paper

Ask AI

Bookmark

Why the study?

Contemporary trends in pulmonary embolism-attributable mortality among US patients with heart failure remain underexplored.

Population

38,129 US patients with HF aged ≥25 years who died from PE

Comparison

Mortality trends stratified by age, sex, race/ethnicity, urbanicity, and region

Design

Retrospective database analysis using CDC WONDER and NHANES

Key result

Between 2010 and 2020, age-adjusted pulmonary embolism-attributable mortality among U.S. patients with heart failure increased by an average of 4.7% annually (95% CI: 3.3%-6.1%; P<0.001).

Authors

MZMarco Zuin ANAnju Nohria SHStanislav Henkin

Discussion

Member takes

Overview

May warrant closer PE monitoring in HF; leaves open optimal prevention strategies.

Key Points

The study evaluates trends in pulmonary embolism-attributable mortality among heart failure patients in the U.S. from 2010 to 2020.
Analyzed data from the CDC database for patients with heart failure aged ≥25 years.
Used joinpoint regression to assess age-adjusted mortality rates and trends.
Examined concurrent trends in heart failure prevalence using National Health and Nutrition Examination Survey data.
38,129 heart failure patients died from pulmonary embolism, with a proportionate mortality of 9.8%.
Age-adjusted mortality rates increased by 4.7% annually, with significant rises for younger adults and certain racial groups.
Concomitant increases in risk factors such as obesity, smoking, and chronic kidney disease were noted.

Study Design

Type

Observational (n=38,129)

Multicenter

Yes

Structured PICO

Population

38,129 U.S. adults aged ≥25 years with heart failure who died from pulmonary embolism between 2010 and 2020.

Outcome

Trends in pulmonary embolism (PE)-attributable mortality (Age-adjusted mortality rates)hard clinical

Main Result

Effect estimate: Average annual percentage change +4.7% (95% CI 3.3%-6.1%)

p-value: p=<0.001

Pulmonary embolism-attributable mortality among U.S. patients with heart failure has risen significantly from 2010 to 2020, particularly among younger adults and certain ethnoracial groups.

Cite This Study

synapsesocial.com/papers/6a35982fdd3be7785e70ecc9 https://doi.org/10.1016/j.jacadv.2026.102841

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