What question did this study set out to answer?

The study aims to explore how mTOR affects the apoptosis of CD4+ T cells through autophagy during sepsis.

February 9, 2026

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Key Points

The study aims to explore how mTOR affects the apoptosis of CD4+ T cells through autophagy during sepsis.
Examined the effects of mTOR deletion on CD4+ T cells
Studied the role of autophagosome-lysosome fusion
Analyzed endpoints related to endoplasmic reticulum stress (ERS) and apoptosis
mTOR deletion significantly alleviated ERS-induced apoptosis in CD4+ T cells
Increased autophagic flux was noted following mTOR deletion
The mTOR-autophagy-ERS-apoptosis axis was established as a novel pathway in sepsis

Abstract

we proved that mTOR deletion could alleviate CD4 + T cells ERS-apoptosis by rescuing autophagy involving autophagosome -lysosome fusion. For the first time, we demonstrate the mTOR-autophagy-ERS-apoptosis axis in sepsis, enriching the targets for future discovery of new sepsis therapies.

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Key Points

Abstract

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