mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Xianli Lei; Guoyu Zhao; Yawen Xie; Na Cui

doi:10.1007/s00011-025-02114-4

February 7, 2026

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to explore how mTOR affects the apoptosis of CD4+ T cells through autophagy during sepsis.
Examined the effects of mTOR deletion on CD4+ T cells
Studied the role of autophagosome-lysosome fusion
Analyzed endpoints related to endoplasmic reticulum stress (ERS) and apoptosis
mTOR deletion significantly alleviated ERS-induced apoptosis in CD4+ T cells
Increased autophagic flux was noted following mTOR deletion
The mTOR-autophagy-ERS-apoptosis axis was established as a novel pathway in sepsis

Implication

Findings reveal mTOR deletion reduces CD4+ T cell apoptosis via autophagy in sepsis, suggesting new therapeutic targets.

Abstract

we proved that mTOR deletion could alleviate CD4 + T cells ERS-apoptosis by rescuing autophagy involving autophagosome -lysosome fusion. For the first time, we demonstrate the mTOR-autophagy-ERS-apoptosis axis in sepsis, enriching the targets for future discovery of new sepsis therapies.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Lei et al. (2026) studied this question.

synapsesocial.com/papers/69897a14f0ec2af6756e8564 https://doi.org/10.1007/s00011-025-02114-4

View Full Paper

Ask AI

Bookmark

Share

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Key Points

Implication

Abstract

Discussion

Cite This Study

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading