What question did this study set out to answer?

To evaluate the effects of caffeine on apnea related to bronchiolitis in infants under 12 months.

February 9, 20260 citations

Caffeine and other methylxanthines' impact on bronchiolitis-related apnea in under 12-months-old children-a systematic review with meta-analyses.

DBDavid BrossierUniversité de Lille DCDamiano CerasuoloCentre Hospitalier Universitaire de Caen Normandie ABAnaïs R. BriantNormandie Université

Key Points

To evaluate the effects of caffeine on apnea related to bronchiolitis in infants under 12 months.
Conducted a systematic review with meta-analysis
Analyzed clinical outcomes related to respiratory support
Assessed methodological limitations in existing studies
No significant improvement in major clinical outcomes was found
Possible reduction in overall respiratory support duration was suggested
Identified critical limitations such as heterogeneous apnea definitions and non-standardized caffeine dosing

Abstract

• This is the first systematic review with meta-analysis evaluating caffeine in BRA, showing no significant improvement in major clinical outcomes, but suggesting a possible reduction in overall respiratory support duration. • The study identifies critical methodological limitations in the existing literature, including heterogeneous apnea definitions and non-standardized caffeine dosing, and proposes a framework for future controlled studies.

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