Tunable Regioselectivity for C-H Alkynylation of Weak Coordinating Amides that Tolerated Strongly Coordinating Heterocycles

Key Points

• The research aims to explore a regioselective C-H alkynylation method using weakly coordinating amides.
• Directed regioselective C-H alkynylation using weakly coordinating amides
• Modification of drug and material analogues
• Evaluation of tolerances for strongly coordinating heterocycles
• Achieved regioselective C-H alkynylation in drug analogues
• Demonstrated site-specific modification capabilities
• Showed tolerance to strongly coordinating heterocycles in reactions