Inductively coupled plasma – mass spectrometry to evaluate the impact of long-term Zn supplementation in liver tissue of APP/PS1 mouse model of Alzheimer's disease

Key Points

• Long-term zinc supplementation impacts liver tissue in the APP/PS1 mouse model for Alzheimer's disease.
• Findings indicate significant changes in liver biomarker levels due to zinc treatment, notably with mass spectrometry techniques.
• Assessment using inductively coupled plasma mass spectrometry highlights molecular changes linked to zinc exposure in the model.
• Results may enable further exploration of zinc’s role in Alzheimer’s pathology and potential therapeutic avenues.