The LDLr(-/-)/ApoB(100/100)/IGF-II mouse serves as a novel preclinical model demonstrating that type 2 diabetes and dyslipidemia contribute to early aortic valve calcification.
We have established the diabetes mellitus -prone LDLr(-/-)/ApoB(100/100)/IGF-II mouse as a new model of calcified aortic valve disease. Our results are consistent with the growing body of clinical evidence that the dysmetabolic state of type 2 diabetes mellitus contributes to early mineralization of the aortic valve and calcified aortic valve disease pathogenesis.
Quang et al. (Fri,) studied this question.