What question did this study set out to answer?

This research aims to investigate the early development of calcific aortic valve disease in a specific mouse model associated with type 2 diabetes.

August 15, 2014Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Early Development of Calcific Aortic Valve Disease and Left Ventricular Hypertrophy in a Mouse Model of Combined Dyslipidemia and Type 2 Diabetes Mellitus

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Population

diabetes mellitus-prone LDLr(-/-)/ApoB(100/100)/IGF-II mouse model

Design

Preclinical

Authors

KQKhaï Le QuangPacific Environment RBRihab BoucharebTemple University DLDominic LachanceLung Institute

Discussion

Member takes

Implication

No change to clinical aortic valve management; leaves open metabolic contributions to human calcification pending validation.

Key Points

This research aims to investigate the early development of calcific aortic valve disease in a specific mouse model associated with type 2 diabetes.
Established the LDLr(-/-)/ApoB(100/100)/IGF-II mouse model of diabetes mellitus.
Examined the relationship between dysmetabolism and aortic valve mineralization.
Results show increased mineralization of the aortic valve in the diabetes model.
Findings align with clinical data indicating a link between type 2 diabetes and calcified aortic valve disease.

Structured PICO

Population

diabetes mellitus-prone LDLr(-/-)/ApoB(100/100)/IGF-II mouse model

Outcome

development of calcific aortic valve disease and left ventricular hypertrophysurrogate

The LDLr(-/-)/ApoB(100/100)/IGF-II mouse serves as a novel preclinical model demonstrating that type 2 diabetes and dyslipidemia contribute to early aortic valve calcification.

Cite This Study

Quang et al. (2014) studied this question.

synapsesocial.com/papers/69b31ef095ae609a79650199 https://doi.org/10.1161/atvbaha.114.304205

Topics

Lipid management

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Early Development of Calcific Aortic Valve Disease and Left Ventricular Hypertrophy in a Mouse Model of Combined Dyslipidemia and Type 2 Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Early Development of Calcific Aortic Valve Disease and Left Ventricular Hypertrophy in a Mouse Model of Combined Dyslipidemia and Type 2 Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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