Why the study?
Diabetes contributes to cardiovascular aortic valve disease with no currently available drug therapy, prompting research into distinctive mechanisms of disease evolution.
Does early type 1 diabetes onset induce molecular and functional changes in aortic heart valves in a hyperlipemic ApoE-/- mouse model?
Population
Hyperlipemic ApoE-/- mouse model
Comparison
Early type 1 diabetes onset at 4 and 7 days after streptozotocin induction
Design
Preclinical animal study
Follow-up
4 and 7 days
Authors
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Hypothesis-generating for rapid aortic valve changes in early diabetes; clinical translation requires prospective human studies.
Does early type 1 diabetes onset induce molecular and functional changes in aortic heart valves in a hyperlipemic ApoE-/- mouse model?
Early type 1 diabetes induces rapid functional and molecular changes, including inflammation and osteogenic marker expression, in the aortic valves of hyperlipidemic mice within one week.
Tucureanu et al. (2019) studied this question.
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