Front Cover: Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation (ChemBioChem 7/2026)

Key Points

• To evaluate the effectiveness of a carborane-based dual inhibitor radiolabeled with iodine-123 for tumor visualization.
• Utilized detection dogs trained to recognize COX-2 and 5-LO enzymes.
• Radiolabeled a dual inhibitor with iodine-123 for imaging purposes.
• Conducted both in vitro and in vivo evaluations using SPECT imaging.
• Detection dogs successfully located tumors that overexpress COX-2 and 5-LO.
• SPECT imaging provided visual confirmation of tumor presence.
• The dual inhibitor showed potential for enhancing tumor visualization techniques.