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March 26, 2026ChemBioChem

Front Cover: Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation (ChemBioChem 7/2026)

Jonas Schädlich Martin Ullrich Cathleen Haase‐Kohn Robert Wodtke Sebastian Braun Maximilian Molitor Bettina Hofmann D Steinhilber K. Kopka Evamarie Hey‐Hawkins Jens Pietzsch Markus Laube

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Key Points

To evaluate the effectiveness of a carborane-based dual inhibitor radiolabeled with iodine-123 for tumor visualization.
Utilized detection dogs trained to recognize COX-2 and 5-LO enzymes.
Radiolabeled a dual inhibitor with iodine-123 for imaging purposes.
Conducted both in vitro and in vivo evaluations using SPECT imaging.
Detection dogs successfully located tumors that overexpress COX-2 and 5-LO.
SPECT imaging provided visual confirmation of tumor presence.
The dual inhibitor showed potential for enhancing tumor visualization techniques.

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Implication

Detection dogs assist in tumor identification using a carborane-based dual inhibitor with SPECT imaging, indicating potential in cancer diagnostics.

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Cite This Study

Schädlich et al. (2026) studied this question.

synapsesocial.com/papers/69c8c2a4de0f0f753b39cfc8 https://doi.org/10.1002/cbic.70336

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