April 16, 2015Open Access

Optimal duration of dual antiplatelet therapy after percutaneous coronary intervention with drug eluting stents: meta-analysis of randomised controlled trials

Structured PICO

Does short term (<12 months) or extended (>12 months) DAPT improve outcomes compared to standard 12-month DAPT in patients after PCI with drug-eluting stents?

Population

Patients after percutaneous coronary intervention (PCI) with drug eluting stents

Intervention

Short term (<12 months) or extended (>12 months) dual antiplatelet therapy (DAPT)

Comparator

Standard 12 month duration of dual antiplatelet therapy (DAPT)

Outcome

Bleeding and ischaemic complicationshard clinical

Short-term DAPT (<12 months) reduces bleeding without increasing ischemic risk for most patients after PCI with DES, while extended DAPT (>12 months) may be considered for high ischemic/low bleeding risk patients despite a potential increase in all-cause mortality.

Abstract

Compared with a standard 12 month duration, short term DAPT (12 months) could be considered. The increase in all cause but not cardiovascular death with extended DAPT requires further investigation.

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