Why the study?
Does short term (<12 months) or extended (>12 months) DAPT improve outcomes compared to standard 12-month DAPT in patients after PCI with drug-eluting stents?
Does short term (<12 months) or extended (>12 months) DAPT improve outcomes compared to standard 12-month DAPT in patients after PCI with drug-eluting stents?
Short-term DAPT (<12 months) reduces bleeding without increasing ischemic risk for most patients after PCI with DES, while extended DAPT (>12 months) may be considered for high ischemic/low bleeding risk patients despite a potential increase in all-cause mortality.
Supports shorter DAPT post-PCI to reduce bleeding; challenges extended use given all-cause mortality increase.
Compared with a standard 12 month duration, short term DAPT (<12 months) after drug eluting stent implementation yields reduced bleeding with no apparent increase in ischaemic complications, and could be considered for most patients. In selected patients with low bleeding risk and very high ischaemic risk, extended DAPT (>12 months) could be considered. The increase in all cause but not cardiovascular death with extended DAPT requires further investigation.
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Navarese et al. (2015) studied this question.
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