Bioconversion properties of the urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) and its antihyperuricemic capacity via regulating metabolic/immune pathways and gut microbiota

Key Points

• This research investigates how fermented Aronia melanocarpa acts as a probiotic to lower urate levels and regulate metabolic pathways.
• Utilized omics analysis to confirm metabolite changes after fermentation.
• Conducted experiments on hyperuricemia (HUA) mice to assess effects of fermented product.
• Measured serum cytokines and monitored the TLR4/MyD88/NF-κB pathway.
• Evaluated the modulation of urate-metabolizing factors and butyrate levels via gut bacteria.
• Fermentation resulted in significant metabolite changes, confirming probiotic efficacy.
• FAR and FARS effectively modulated serum cytokines in HUA mice.
• Suppression of the TLR4/MyD88/NF-κB pathway was observed.
• Increased levels of butyrate were linked to shifts in gut microbiota.