Bioconversion properties of the urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) and its antihyperuricemic capacity via regulating metabolic/immune pathways and gut microbiota

Hongyu Zhang; Chaoran Li; Tianjiao Li; Fuyu Li; Xinyu Cao; Yang Yang; Da Wang; Mingyou Yuan; Qiuyi Li; Xuebo Liu; Mengge Zhao

doi:10.1039/d6fo00440g

January 1, 2026Food & Function

Bioconversion properties of the urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) and its antihyperuricemic capacity via regulating metabolic/immune pathways and gut microbiota

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Key Points

This research investigates how fermented Aronia melanocarpa acts as a probiotic to lower urate levels and regulate metabolic pathways.
Utilized omics analysis to confirm metabolite changes after fermentation.
Conducted experiments on hyperuricemia (HUA) mice to assess effects of fermented product.
Measured serum cytokines and monitored the TLR4/MyD88/NF-κB pathway.
Evaluated the modulation of urate-metabolizing factors and butyrate levels via gut bacteria.
Fermentation resulted in significant metabolite changes, confirming probiotic efficacy.
FAR and FARS effectively modulated serum cytokines in HUA mice.
Suppression of the TLR4/MyD88/NF-κB pathway was observed.
Increased levels of butyrate were linked to shifts in gut microbiota.

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Implication

Demonstrates the antihyperuricemic capacity in HUA mice, indicating potential for metabolic and immune pathway regulation.

Abstract

First, omics confirms metabolite changes after fermentation. In HUA mice, FAR and FARS modulate serum cytokines, suppress TLR4/MyD88/NF-κB pathway, and regulate urate-metabolizing factors. Plus, they elevate butyrate via guiding gut bacteria.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a3e5652765b073a72af https://doi.org/10.1039/d6fo00440g

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Bioconversion properties of the urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) and its antihyperuricemic capacity via regulating metabolic/immune pathways and gut microbiota

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Bioconversion properties of the urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) and its antihyperuricemic capacity via regulating metabolic/immune pathways and gut microbiota

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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