Patients with HFrEF had significantly lower percent predicted peak oxygen uptake (65.9%) compared to those with HFpEF (76.6%) and HFmrEF (76.8%), showing a non-linear pattern of exercise capacity.
Observational (n=196)
No
Does exercise capacity and comorbidity profile differ across heart failure ejection fraction categories (HFpEF, HFmrEF, HFrEF)?
Absolute Event Rate: 65.9% vs 76.6%
p-value: p=<0.001
This study aimed to compare exercise capacity (EC) and comorbidity profiles across left ventricular ejection fraction (LVEF) defined heart failure (HF) categories. From a retrospective, single-centre registry, we analysed 196 individuals with established HF who underwent cardiopulmonary exercise testing and a 6 min walk test (6MWT). EC differed significantly across LVEF categories but not in a linear fashion. The percent of predicted peak oxygen uptake (VO₂) was significantly lower in HF with reduced LVEF (HFrEF, n = 89) than in HF with preserved LVEF (HFpEF, n = 36) and HF with mildly reduced LVEF (HFmrEF, n = 71) (65.9% vs. 76.6% and 76.8%, p 36 did not differ across groups. The achieved workload and 6MWT distance were comparable across groups. Comorbidity profiles diverged meaningfully: HFmrEF had the lowest prevalence of chronic kidney disease (p = 0.009) and type 2 diabetes (p = 0.025). Notably, HFpEF exhibited the highest prevalence of anaemia (p = 0.0013). HFmrEF displays an EC profile closer to HFpEF than to HFrEF, while anaemia emerges as a particularly important comorbidity in HFpEF.
Kurpaska et al. (Thu,) conducted a observational in Heart failure (n=196). Left ventricular ejection fraction (LVEF) stratification vs. HFpEF vs HFmrEF vs HFrEF was evaluated on Percent of predicted peak oxygen uptake (peak VO2 %pred) (p=<0.001). Patients with HFrEF had significantly lower percent predicted peak oxygen uptake (65.9%) compared to those with HFpEF (76.6%) and HFmrEF (76.8%), showing a non-linear pattern of exercise capacity.