Is circulating ox-LDL associated with fibrocalcific remodelling of the aortic valve in patients with aortic stenosis?
Increased circulating ox-LDL is associated with worse fibrocalcific remodeling of the aortic valve in patients with aortic stenosis, though its causal role remains to be determined.
Increased level of circulating ox-LDL is associated with worse fibrocalcific remodelling of valvular tissue in AS. It remains to be determined whether circulating ox-LDL is a risk marker for a highly atherogenic profile and/or a circulating molecule which is actively involved in the pathogenesis of calcific aortic valve disease.
Côté et al. (2007) studied this question.