Why the study?
Is circulating ox-LDL associated with fibrocalcific remodelling of the aortic valve in patients with aortic stenosis?
Is circulating ox-LDL associated with fibrocalcific remodelling of the aortic valve in patients with aortic stenosis?
Increased circulating ox-LDL is associated with worse fibrocalcific remodeling of the aortic valve in patients with aortic stenosis, though its causal role remains to be determined.
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Ox-LDL measurement should not yet guide aortic stenosis management; hypothesis-generating for its role in fibrocalcific remodeling.
Increased level of circulating ox-LDL is associated with worse fibrocalcific remodelling of valvular tissue in AS. It remains to be determined whether circulating ox-LDL is a risk marker for a highly atherogenic profile and/or a circulating molecule which is actively involved in the pathogenesis of calcific aortic valve disease.
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Côté et al. (2007) studied this question.
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