Lp(a) and OxPL are implicated in driving valve calcification and progression of aortic stenosis, providing a mechanistic rationale for future clinical trials targeting these pathways.
In patients with AS, Lp(a) and OxPL drive valve calcification and disease progression. These findings suggest lowering Lp(a) or inactivating OxPL may slow AS progression and provide a rationale for clinical trials to test this hypothesis.
Zheng et al. (Mon,) studied this question.