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April 29, 2019Journal of the American College of Cardiology334 citationsOpen Access

Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis

KZKang H. ZhengSTSotirios TsimikasTPTania Pawade

Key Points

  • Determine the impact of lipoprotein(a) and oxidized phospholipids on valve calcification and disease progression in patients with aortic stenosis.
  • Assessed the association between circulating levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids (OxPL) with aortic valve calcification and stenosis severity.

Structured PICO

P
Population
Patients with aortic stenosis (AS)
O
Outcome
Valve calcification and disease progressionsurrogate

Lp(a) and OxPL are implicated in driving valve calcification and progression of aortic stenosis, providing a mechanistic rationale for future clinical trials targeting these pathways.

Abstract

In patients with AS, Lp(a) and OxPL drive valve calcification and disease progression. These findings suggest lowering Lp(a) or inactivating OxPL may slow AS progression and provide a rationale for clinical trials to test this hypothesis.

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Cite This Study

Zheng et al. (2019) studied this question.

synapsesocial.com/papers/69b2b34763dab95dd9c1b7c7https://doi.org/10.1016/j.jacc.2019.01.070
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