Low-dose theophylline in mild to moderate Chronic Obstructive Pulmonary Disease: A randomized clinical trial in China

Key Points

• This study aims to assess the effects of low-dose theophylline on lung function and exacerbation rates in patients with mild to moderate COPD.
• Conducted as a randomized clinical trial
• Included individuals diagnosed with mild to moderate COPD
• Administered low-dose theophylline and monitored lung function parameters
• Low-dose theophylline was well-tolerated among participants
• Did not significantly reduce exacerbation rates
• Showed a modest improvement in pre-bronchodilator FEV1, though limited in magnitude