Randomized trial evaluates low-dose theophylline in COPD, showing limited impact on lung function and exacerbations.
In mild to moderate COPD, low-dose theophylline was well-tolerated but did not reduce exacerbation rates. A modest improvement in pre-bronchodilator FEV₁ was observed, though its magnitude was limited. Larger trials are needed to further evaluate its potential to improve lung function in this population.
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Zhou et al. (2026) studied this question.
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