This novel diet- and chemical-induced murine NASH model accurately recapitulates human fatty liver disease progression, providing a reproducible platform for studying pathogenesis and testing new treatments.
A carefully characterized model has been developed in mice that recapitulates the progressive stages of human fatty liver disease, from simple steatosis, to inflammation, fibrosis and cancer. The functional pathways of gene expression and immune abnormalities in this model closely resemble human disease. The ease and reproducibility of this model make it ideal to study disease pathogenesis and test new treatments.
Tsuchida et al. (Wed,) studied this question.