March 21, 2018Journal of HepatologyOpen Access

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

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Population

mice

Design

Preclinical

Authors

TTTakuma TsuchidaWaseda University YLYoungmin A. LeeVanderbilt University Medical Center NFNaoto FujiwaraMie University

Discussion

Member takes

Implication

May enable preclinical NASH therapy testing; leaves open human translation pending validation.

Structured PICO

Population

mice

Intervention

diet- and chemical-induced NASH model

Outcome

recapitulation of progressive stages of human fatty liver disease (steatosis, inflammation, fibrosis, and cancer)surrogate

This novel diet- and chemical-induced murine NASH model accurately recapitulates human fatty liver disease progression, providing a reproducible platform for studying pathogenesis and testing new treatments.

Cite This Study

Tsuchida et al. (2018) studied this question.

synapsesocial.com/papers/69d968e48988aeabbe6852cc https://doi.org/10.1016/j.jhep.2018.03.011

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A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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