Increased local production of endothelin-1 in vascular endothelial cells may contribute to the vascular abnormalities associated with pulmonary hypertension.
Pulmonary hypertension is associated with the increased expression of endothelin-1 in vascular endothelial cells, suggesting that the local production of endothelin-1 may contribute to the vascular abnormalities associated with this disorder.
Giaid et al. (Thu,) studied this question.