November 18, 1997

Significance of Ventricular Myocytes and Nonmyocytes Interaction During Cardiocyte Hypertrophy

Structured PICO

Population

Ventricular myocytes (MCs) and nonmyocytes (NMCs)

Intervention

Ang II or TGF-beta1

Outcome

Cardiocyte hypertrophysurrogate

Ventricular nonmyocytes play a critical role in regulating myocyte hypertrophy induced by Ang II or TGF-beta1, partially through ET-1 secretion.

Abstract

These results demonstrate that NMCs regulate MC hypertrophy at least partially via ET-1 secretion and that the interaction between MCs and NMCs plays a critical role during the process of Ang II- or TGF-beta1-induced cardiocyte hypertrophy.

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Cite This Study

Harada et al. (Tue,) studied this question.

synapsesocial.com/papers/69de72fcfd84e72eb2558551 https://doi.org/https://doi.org/10.1161/01.cir.96.10.3737

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