Population
Ventricular myocytes (MCs) and nonmyocytes (NMCs)
Design
Preclinical
Authors
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Should not yet change clinical practice in hypertrophy; hypothesis-generating for nonmyocyte-myocyte interactions in remodeling.
Ventricular nonmyocytes play a critical role in regulating myocyte hypertrophy induced by Ang II or TGF-beta1, partially through ET-1 secretion.
Harada et al. (1997) studied this question.
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