Do mutations of the RyR2 gene cause familial polymorphic ventricular tachycardia?
Mutations in the RyR2 gene are identified as a cause of familial polymorphic ventricular tachycardia, establishing a new class of myocardial calcium signaling disorders.
Our data illustrate that mutations of the RyR2 gene cause at least one variety of inherited polymorphic tachycardia. These findings define a new entity of disorders of myocardial calcium signaling.
Laitinen et al. (2001) studied this question.