Why the study?
Do mutations of the RyR2 gene cause familial polymorphic ventricular tachycardia?
Do mutations of the RyR2 gene cause familial polymorphic ventricular tachycardia?
Mutations in the RyR2 gene are identified as a cause of familial polymorphic ventricular tachycardia, establishing a new class of myocardial calcium signaling disorders.
Supports targeted RyR2 testing in familial polymorphic VT; leaves open broader phenotypic spectrum and therapies.
Our data illustrate that mutations of the RyR2 gene cause at least one variety of inherited polymorphic tachycardia. These findings define a new entity of disorders of myocardial calcium signaling.
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Laitinen et al. (2001) studied this question.
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