What does this research mean for the field?

Greater annualized eGFR improvement with GLP-1 receptor agonists is associated with larger reductions in clinical heart failure events, indicating eGFR change may serve as a useful marker of heart failure benefit. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the relationship between estimated glomerular filtration rate (eGFR) changes and heart failure (HF) events in patients treated with GLP-1 receptor agonists.

April 15, 2026Diabetes Obesity and Metabolism1 citationsOpen Access

Estimated Glomerular Filtration Rate Change and Heart Failure Events With GLP ‐1 Receptor Agonists: A Meta‐Analysis and Meta‐Regression of Randomised Controlled Trials

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MHMasashi HasebeKyoto University HKHisashi KamidoToranomon Hospital CSChen‐Yang Su

Key Points

To investigate the relationship between estimated glomerular filtration rate (eGFR) changes and heart failure (HF) events in patients treated with GLP-1 receptor agonists.
Performed a meta-analysis of randomized controlled trials involving GLP-1 receptor agonists.

Structured PICO

Is annualised eGFR change associated with reductions in clinical heart failure events with GLP-1 receptor agonists?

Population

Patients in large-scale GLP-1 receptor agonist randomised controlled trials

Intervention

GLP-1 receptor agonists

Outcome

Clinical heart failure events and annualised eGFR change

Annualised eGFR change may serve as a useful marker of heart failure benefit with GLP-1 receptor agonists.

Abstract

Across large-scale GLP-1RA trials, greater annualised eGFR improvement was associated with larger reductions in clinical HF events. Annualised eGFR change may serve as a useful marker of HF benefit with GLP-1RAs.

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View Full Paper

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View Full Paper

Estimated Glomerular Filtration Rate Change and Heart Failure Events With GLP ‐1 Receptor Agonists: A Meta‐Analysis and Meta‐Regression of Randomised Controlled Trials

Key Points

Structured PICO

Abstract

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