Ball-Milling Synthesis of α-Bromoacrylates from Solvent-free In-Situ Prepared Ethyl Diethylbromophosphonate

Key Points

• The aim is to describe a novel ball-milling method for synthesizing α-bromoacrylates from triethyl phosphonoacetate.
• Ball-milling-assisted bromination and HWE process
• Optimization of bromination and HWE protocols under mechanochemical conditions
• One-pot synthesis approach
• Successful synthesis of α-bromoacrylates from triethyl phosphonoacetate
• Demonstrated efficiency of the ball-milling process
• Reduction in solvent use during the synthesis