NLRP3 Inflammasome Activation Mediates Coronary Artery Lesions in Kawasaki Disease by Inducing Endothelial Cells Pyroptosis and Glycocalyx Injury

Key Points

• The study aims to explore the link between NLRP3 inflammasome activation and endothelial injury in Kawasaki Disease.
• Analyzed the role of NLRP3 inflammasome in Kawasaki Disease progression.
• Examined the effects of NLRP3 activation on endothelial cells.
• Investigated the mechanisms behind pyroptosis and glycocalyx injury.
• NLRP3 activation leads to enhanced endothelial cell pyroptosis.
• Glycocalyx injury is associated with inflammatory imbalance.
• Targeting NLRP3 shows potential as a therapeutic strategy.