What question did this study set out to answer?

This research aims to explore the antihyperglycemic and antioxidant effects of hispidulin through key molecular pathways.

April 22, 2026Open Access

Hispidulin: A potential antihyperglycemic and anti-oxidant agent-mechanistic insights into its modulatory effects on PI3K, AKT, mTOR, IRS1, GSK-3β, and GLUT-4 pathways through in vitro and in vivo studies.

Key Points

This research aims to explore the antihyperglycemic and antioxidant effects of hispidulin through key molecular pathways.
Conducted in vitro and in vivo experiments to assess the effects of hispidulin on insulin sensitivity.
Analyzed modulation of genes involved in the PI3K/AKT pathway.
Evaluated reductions in oxidative stress and inflammation.
Hispidulin significantly improved insulin sensitivity and reduced oxidative stress.
Activation of PI3K/AKT pathway components was observed.
Results suggest enhanced modulation of GLUT-4, contributing to better glucose uptake.

Abstract

Hispidulin exhibits potent antidiabetic properties by improving insulin sensitivity, reducing oxidative stress and inflammation, and modulating key genes in the PI3K/AKT pathway. These findings suggest hispidulin as a therapeutic agent for managing type 2 diabetes mellitus.

Hispidulin: A potential antihyperglycemic and anti-oxidant agent-mechanistic insights into its modulatory effects on PI3K, AKT, mTOR, IRS1, GSK-3β, and GLUT-4 pathways through in vitro and in vivo studies.

Key Points

Abstract

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