What question did this study set out to answer?

The aim is to analyze trends in pulmonary mold infections among hematologic malignancy patients over the past decade.

April 23, 2026Open Access

A decade of change: evolving epidemiology of invasive pulmonary mold infections in hematologic malignancy patients from a longitudinal infection control surveillance program

GHGuy Handley JPJane PowellThe University of Texas MD Anderson Cancer Center DKDimitrios P. Kontoyiannis

Key Points

The aim is to analyze trends in pulmonary mold infections among hematologic malignancy patients over the past decade.
Analysis of 227 pulmonary mold infection cases through infection control surveillance.
Comparison of late-onset infections and their causative agents over two time periods: 2014-2019 and 2020-2025.
Late-onset pulmonary mold infections decreased in the prevalence of Aspergillus from 86.7% to 11.1% (P < .001).
Fusarium spp. infections increased significantly from 0% to 44.4% for late-onset cases (P = .012).

Abstract

Epidemiologic trends in pulmonary mold infections were assessed. Of 227 infections, 24 were considered late-onset (>14 days) and Aspergillus less common (58.3% vs 78.3%; P = .030). For late-onset cases, Aspergillus was dramatically less frequent from 2020-2025 compared to 2014-2019 (11.1% vs 86.7%, P < .001), while Fusarium spp. increased (44.4% vs 0%, P = .012).

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