Of time, space, and closed-loop deep brain stimulation

Key Points

• This commentary evaluates the implications of spatial dynamics in deep brain stimulation on Parkinson's treatment.
• Analysis of the commentary on basal ganglia activity and its relationship to motor states in Parkinson's disease.
• Discussion on the closed-loop stimulation approach and its relevance to spatial propagation.
• Spatial propagation of movement-related activity is linked to parkinsonian motor states.
• Closed-loop deep brain stimulation could enhance therapeutic outcomes by targeting these dynamics.