Discovery of New OTUB1 Covalent Ligands via Structure–Activity Relationship Studies for Targeted Protein Stabilization | Synapse
May 7, 2026
Discovery of New OTUB1 Covalent Ligands via Structure–Activity Relationship Studies for Targeted Protein Stabilization
Key Points
The research aims to discover new covalent ligands for OTUB1 to improve targeted protein stabilization.
Conducted structure–activity relationship studies
Developed CFTR DUBTAC
Evaluated ligands for OTUB1
Expanded existing DUB ligands
Identified novel OTUB1 covalent ligands
Improved the range of available DUB ligands
Enhanced capabilities for targeted protein stabilization
Abstract
, we developed an effective CFTR DUBTAC. Overall, we developed new and improved OTUB1 covalent ligands, expanding the limited number of DUB ligands that can be harnessed for TPS.