Discovery of New OTUB1 Covalent Ligands via Structure–Activity Relationship Studies for Targeted Protein Stabilization

Xiangyang Song; Qiong Wu; Li Chen; Hiroyuki Inuzuka; Yue Zhong; Yihang Qi; Yindan Lin; Md Kabir; Yan Xiong; Wenyi Wei; Jian Jin

doi:10.1021/acs.jmedchem.5c03327

May 4, 2026Journal of Medicinal Chemistry

Discovery of New OTUB1 Covalent Ligands via Structure–Activity Relationship Studies for Targeted Protein Stabilization

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Key Points

The research aims to discover new covalent ligands for OTUB1 to improve targeted protein stabilization.
Conducted structure–activity relationship studies
Developed CFTR DUBTAC
Evaluated ligands for OTUB1
Expanded existing DUB ligands
Identified novel OTUB1 covalent ligands
Improved the range of available DUB ligands
Enhanced capabilities for targeted protein stabilization

Implication

Research demonstrates new covalent ligands for OTUB1, suggesting targeted protein stabilization can be enhanced.

Abstract

, we developed an effective CFTR DUBTAC. Overall, we developed new and improved OTUB1 covalent ligands, expanding the limited number of DUB ligands that can be harnessed for TPS.

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Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/69fbf004164b5133a91a42bb https://doi.org/10.1021/acs.jmedchem.5c03327

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Discovery of New OTUB1 Covalent Ligands via Structure–Activity Relationship Studies for Targeted Protein Stabilization

Key Points

Implication

Abstract

Discussion

Cite This Study

Discovery of New OTUB1 Covalent Ligands via Structure–Activity Relationship Studies for Targeted Protein Stabilization

Key Points

Implication

Abstract

Discussion

Cite This Study

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